Exercise Health Essay Example | Topics and Well Written Essays - 750 words

Exercise Health - Essay Example Kumar et al in their book Pathologic basis of disease, refer to cardiovascular disease as the single greatest killer of humanity in industrialized nations, accounting for more than 5 million deaths per year. Sedentary living and the associated cardiorespiratory diseases are regarded by Bouchard and Blair as the major factors responsible for premature deaths in this century. Hypertension and obesity are the initial manifestations of disease as the body starts accumulating fats due to the lack of physical activity. Soon the blood vessels become clogged due to the deposition of fibrous plaques, leading to increased blood pressure. Canlas describes hypertension as the silent killer, because it causes extensive damage internally long before the external manifestations of the disease. It is therefore important to realize the importance of exercise and incorporate it in a daily routine to nip the problem in the bud. Fletcher et al in their statement on exercise state the fundamental role of physical activity to counter the cardiovascular accidents. According to them, exercise increases the functional capacity of the heart and reduces the myocardial oxygen demand. Exercise minimizes the chances of adverse cardiac events in normal population and in rehabilitation of patients who have survived a prior attack. Regular routine improves calcium deposition in bones, thereby increasing bone density and reducing the risk of bone break disease, osteoporosis. Siscovick et al highlight the importance of adopting a regular exercise routine in order to maintain the bone strength and flexibility especially after menopause. The effects of exercise on muscular system are evident as an improvement in endurance and power on account of resistance training. Bouchard et al propose a regular exercise routine because it ensures an adequate fat distribution over the body and the normal body mass index as well as counter the metabolic disturbances leading to the development of diabetes and abn ormal lipid profiles. Chesley et al highlight the effects of exercise when accompanied by adequate protein intake, as it helps shed excessive fat and shifts the muscle protein turn over towards the synthesis of new proteins resulting in increased lean muscle mass. As evident, the benefits of exercise are numerous and the risks are minor or limited to some exceptional cases. Care should be taken when designing the exercise plan for hypertensive people or the survivors of congestive cardiac failure as they have limited reserve of cardiac and respiratory functional capacity. Siscovick et al describe the benefits of starting from light aerobics and moving onto resistance training exercises as they prove beneficial in the long run, as manifested by increase in strength and endurance, and a lower level blood pressure. Bouchard et al also advocate this approach as a step to reduce the over all chances of recurrence of adverse cardiac events and support the fact that a carefully designed ex ercise regimen should dismisses the myth about exercise being dangerous for health. When talking about the sedentary life style in developed countries, the referred target population is the one with great jobs and the policy makers who employ masses for the tasks to be performed, while their own job is limited to sitting at the desk behind a screen to make and manage the policies and

Pharmacology (Drug Profile Midazolam) Essay Example | Topics and Well Written Essays - 2750 words

Pharmacology (Drug Profile Midazolam) - Essay Example b) Oral administration is also done for short term treatment. This is done mainly for the insomnia patients. c) Midazolam is also indicted for the management of schizopernia. 3. Midazolam is found to interact with many drugs. The drug interaction is found to either increase the activity or decrease the activity of Midazoalm. The drug interaction occurs mainly with the antipsychotic medications, barbiturates, antibiotics and antifungal, cimetidine, Diltiazem, Narcotics, Seizure and Sleep medications, alcohol and antidepressant medicines such as Antipsychotic drugs include: Aripipraxole , asenapine, chlorpromazine, clozapine, fluphenazine, haloperidol, Iloperidone, loxapine, lurasidone, molindone, olanzapine, paliperidone and perphenazine and pimozide. Barbutarates include: Amobarbital, Butalbital, Pentobarbital and Secobarbital. Antibiotics such as Clarithomycin, Erythromycin, Isoniazid, Itraconazole , ketoconazole and Telithromycin. Narcotics such as morphine and oxycodone are used i n combination with Midazolam. (drugs.emedtv.com) The pharmacokinetic drug interactions are found to occur based on the enzymes involved in the metabolism. The drug interaction with the CNS depressants such as alcohols, opioids and barbiturates are found to have lethal, clinical and forensic consequences with midazolam. Many studies have found that this interaction results in death. (Mozayani and Raymon 2004). Similarly when analgesics are used along with the midazolam, they are found to have greater sedative effects. The gastrointestinal agents when combined with midazolam are found to increase the rate of absorption of the drug. Cimetidine when used along with Midazolam is found to increase the retention time of Midazolam in the body. Similarly the antifungal agents are also found to inhibit the movement of Midazolam from the body. 4. a) The mechanism of interaction of Midozolam is understood well. The main target of Midazolam is the GABAa receptor. This is an ionotropic receptor w ith gamma amino butyric acid as the endogenous ligand. When GABAa receptor is activated then it transmits Chloride ions through their pores and polarizes the neurons. This polarization results in the inhibition of the neurotransmission. The benzodiazepines binds to the receptor found between the alpha and gamma receptor subunits. The five subunits of GABA receptor are sensitive to benzodiazepine. When benzodiazepine binds to the alpha and the gamma subunits of the GABA receptor, and brings the receptor into its control. The binding brings out a change in the conformation of the GABA – alpha and makes them to open the chloride ion channel and this polarizes the membrane. This process inhibits the signal transduction pathway by arresting the GABA molecules and creating sedatory and anxiolytic effects to the human. (Sigel 2002). b. Midozolam is the substrate for the receptor GABA only. This is very specific in nature. It binds to the GABA receptors that are having only alpha and gamma subunits. The binding of benzodiazepine modifies the GABAs response by the receptor. As these receptors are found in the cerebral cortex region, limbic system, cerebellar cortex and spinal cord, its effect can be felt in many parts of the body. The two compartmental model enables the specificity of the molecule and increases the sensitivity. (Stoelting and Miller 2007) c.